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Lithiated Benzothiophenes and Benzofurans Require 2-Silyl Protection to Avoid Anion Migration

Marvin M. Hansen*a, Marcella T. Claytona, Alexander G. Godfreya, John L. Grutsch Jr.a, Sandra S. Keasta, Dan T. Kohlmanb, Andreea R. McSpaddena, Steven W. Pedersena, Jeffrey A. Warda, Yao-Chang Xub
a Chemical Product Research and Development, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indiananapolis, IN 46285, USA
b Discovery Chemistry, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indiananapolis, IN 46285, USA
Fax: +1(317)2764507; e-Mail: mmh@lilly.com;