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Synthesis 2004(7): 0992-0994  
DOI: 10.1055/s-2004-822345
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

Strategies for the Preparation of (1-Acetyloxyethylidene)-1,1-bisphosphonic Acid Derivatives

Petri A. Turhanen*, Jouko J. Vepsäläinen
University of Kuopio, Department of Chemistry, P.O. Box 1627, 70211 Kuopio, Finland
Fax: +358(17)163259; e-Mail: Petri.Turhanen@uku.fi;
Further Information

Publication History

Received 17 February 2004
Publication Date:
25 April 2004 (online)

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Abstract

The novel strategies for the synthesis of acetylated etidronic acid derivatives were investigated. (1-Acetyloxyethylidene)-1,1-bisphosphonic acid and its P,P′-dimethyl, trimethyl and tetramethyl esters were prepared in high 81-100% yields.

Key words

bisphosphonate - etidronate - partial esters - synthesis - prodrug

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