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Synthesis 2004(3): 373-376
DOI: 10.1055/s-2004-815950
DOI: 10.1055/s-2004-815950
PAPER
© Georg Thieme Verlag Stuttgart · New YorkA Facile Route to Pyrrolo[3′,4′:3,4]pyrido[1,2-a]benzimidazoles, Novel Heterocyclic Derivatives
Further Information
Received
3 August 2003
Publication Date:
03 February 2004 (online)
Publication History
Publication Date:
03 February 2004 (online)

Abstract
The title system derivatives were prepared in two steps. Thus the condensation of 2-benzimidazoleacetonitrile with ethyl 4-chloro-3-oxobutanoate led to the 3-chloromethyl-1,5-dihydro-1-oxopyrido[1,2-a]benzimidazole-4-carbonitrile. Further amination of the obtained chloronitrile with primary amines yielded 1-amino-2,3-dihydro-2-R-5H-pyrrolo[3′,4′:3,4]pyrido[1,2-a]benzimidazol-5-ones.
Key words
alkylations - 2-benzimidazoleacetonitrile - heterocycles - pyrrolo[3′,4′:3,4]pyrido[1,2-a]benzimidazoles - ring closure
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