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Synthesis 2004(4): 509-516
DOI: 10.1055/s-2004-815939
DOI: 10.1055/s-2004-815939
PAPER
© Georg Thieme Verlag Stuttgart · New YorkSynthesis of AZT/d4T Boranophosphates as Anti-HIV Prodrug Candidates
Further Information
Received
4 December 2003
Publication Date:
03 February 2004 (online)
Publication History
Publication Date:
03 February 2004 (online)
Abstract
AZT/d4T phosphonates were synthesized by sequential condensation of AZT/d4T with the corresponding alcohols or 5′-DMT-thymidine in the presence of pivaloyl chloride. Sequential silylation, boronation, and hydrolysis in ammonium hydroxide of these phosphonates led to anti-HIV prodrug candidates AZT/d4T boranophosphates.
Key words
anti-HIV - AZT - d4T - phosphonate - boranophosphate
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