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DOI: 10.1055/s-2003-45477
© Georg Thieme Verlag Stuttgart · New York
Hepatische Enzephalopathie - Therapie
Hepatic encephalopathy - therapyPublikationsverlauf
eingereicht: 16.10.2003
akzeptiert: 13.11.2003
Publikationsdatum:
15. Dezember 2003 (online)

Die primären therapeutischen Maßnahmen bei hepatischer Enzephalopathie bestehen in der Erkennung und Beseitigung auslösender Faktoren. Die weitere Therapie zielt in erster Linie auf eine Verringerung der Bildung und Resorption toxischer Metabolite im Darm mittels Eiweißrestriktion, Laktulose und oraler Antibiotika. L-Ornithin-L-Aspartat verbessert die Ammoniakentgiftung und die klinische Symptomatik. Bei hepatischer Enzephalopathie im Rahmen eines akuten Leberversagens können hirndrucksenkende Maßnahmen erforderlich sein.
Literatur
- 1
Conn H O, Leevy C M, Vlahcevic Z R, Rodgers J B. et al .
Comparison of lactulose and neomycin in the treatment of chronic portal-systemic
encephalopathy: a double-blind controlled trial.
Gastroenterology.
1977;
72
573-578
MissingFormLabel
- 2
Häussinger D, Steeb R, Gerok W.
Metabolic alkalosis as driving force for urea synthesis in liver disease: pathogenic
model and therapeutic implications.
Clin Invest.
1992;
70
411-415
MissingFormLabel
- 3
Heemann U, Treichel U, Loock J, Philipp T. et al .
Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective,
controlled study.
Hepatology.
2002;
36
949-958
MissingFormLabel
- 4
Horst D, Grace N D, Conn H O, Schiff E. et al .
Comparison of dietary protein with an oral, branched chain-enriched amino acid
supplement in chronic portal-systemic encephalopathy: a randomized controlled
trial.
Hepatology.
1984;
4
279-287
MissingFormLabel
- 5
Huber M, Rössle M, Siegerstetter V, Ochs A. et al .
Helicobacter pylori infection does not correlate with plasma ammonia concentration
and hepatic encephalopathy in patients with cirrhosis.
Hepatogastroenterology.
2001;
48
541-544
MissingFormLabel
- 6
Kircheis G, Nilius R, Berndt H, Buchner M. et al .
Therapeutic efficacy of L-ornithine-L-aspartate infusion concentrate in patients
with liver cirrhosis and hepatic encephalopathy: A placebo-controlled double-blind
study.
Hepatology.
1997;
25
1351-1360
MissingFormLabel
- 7
Kircheis G, Wettstein M, vom Dahl S, Häussinger D.
Clinical efficacy of L-ornithine-L-asparate in the management of hepatic encephalopathy.
Metabolic Brain Disease.
2002;
17
453-462
MissingFormLabel
- 8
Laccetti M, Manes G, Uomo G, Lionello M. et al .
Flumazenil in the treatment of acute hepatic encephalopathy in cirrhotic patients:
a double blind randomized placebo controlled study.
Dig Liv Dis.
2000;
32
335-338
MissingFormLabel
- 9
Marchesini G, Dioguardi F S, Bianchi G P. et al .
Long-term oral branched-chain amino acid treatment in chronic hepatic encephalopathy.
A randomized double-blind casein-controlled trial J Hepatol.
1990;
11
1-10
MissingFormLabel
- 10
Marchesini G, Fabbri A, Bianchi G, Brizi M, Zoli M.
Zinc supplementation and amino acid-nitrogen metabolism in patients with advanced
cirrhosis.
Hepatology.
1996;
23
1084-1092
MissingFormLabel
- 11
Mas A, Rodés J, Sunyer L, Rodrigo L. et al .
Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy:
results of a randomized, double-blind, double-dummy, controlled trial.
J Hepatol.
2003;
38
51-58
MissingFormLabel
- 12
Morgan M Y, Hawley K E.
A randomized double-blind trial of lactitol and lactulose in acute hepatic encephalopathy
in cirrhotic patients.
Hepatology.
1987;
7
1278-1284
MissingFormLabel
- 13
Naylor C D, O’Rourke K, Detoky A J, Baker J P.
Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy:
A meta-analysis.
Gastroenterology.
1989;
97
1033-1042
MissingFormLabel
- 14
Stauch S, Kircheis G, Adler G, Beckh K. et al .
L-ornithine-L-aspartate granulate in the treatment of latent and mild chronic
hepatic encephalopathy (HE): A placebo-controlled double-blind study.
Journal of Hepatology.
1998;
28
856-864
MissingFormLabel
- 15
Uribe M, Campollo O, Vargas F, Ravelli G P. et al .
Acidifying enemas (lactitol and lactose) versus nonacidifying enemas (tap water)
to treat acute portal-systemic encephalopathy: a double-blind randomized clinical
trial.
Hepatology.
1987;
7
639-643
MissingFormLabel
- 16
Tromm A, Griga T, Greving I, Hilden H. et al .
Orthograde whole gut irrigation with mannite versus paromomycine + lactulose
as prophylaxis of hepatic encephalopathy in patients with cirrhosis and upper
gastrointestinal bleeding: results of a controlled randomized trial.
Hepatogastroenterology.
2000;
47
473-477
MissingFormLabel
- 17
Schepke M, Reichel C, Ziske C, Spengler U, Caselmann W H, Sauerbruch T.
Leberzirrhose - Komplikationen und Therapie.
Dtsch Med Wochenschr.
2001;
36
975-984
MissingFormLabel
Prof. Dr. med. Matthias Wettstein
Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum
Düsseldorf
Moorenstraße 5
40225 Düsseldorf
Telefon: 0211/8116330
Fax: 0211/8118752
eMail: wettstein@med.uni-duesseldorf.de