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Synlett 2004(1): 128-130
DOI: 10.1055/s-2003-44995
DOI: 10.1055/s-2003-44995
LETTER
© Georg Thieme Verlag Stuttgart · New Yorkl-Proline Promoted Ullmann-Type Coupling Reactions of Aryl Iodides with Indoles, Pyrroles, Imidazoles or Pyrazoles
Further Information
Received
16 October 2003
Publication Date:
17 December 2003 (online)
Publication History
Publication Date:
17 December 2003 (online)
Abstract
The Ullmann-type coupling reactions of aryl iodides and several nitrogen heterocycles occur at 80-90 °C with l-proline as additive, giving N-arylpyrroles, N-arylindoles, N-arylimidazoles, and N-pyrazoles in good to excellent yields.
Key words
cross coupling - nitrogen heterocycles - catalysis - aryl iodide - additive
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References
For CuI catalyzed coupling reaction of amides with aryl halides under mild conditions, see ref. [5b] . We are investigating this coupling reaction using our conditions and the results will be reported in due course.