Synthesis 2004(1): 147-150  
DOI: 10.1055/s-2003-42489
PSP
© Georg Thieme Verlag Stuttgart · New York

Preparation of Butane-1,2-diacetal-protected l-Glyceraldehyde from d-Mannitol

Steven V. Ley*, Patrick Michel
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
e-Mail: [email protected];
Further Information

Publication History

Received 12 September 2003
Publication Date:
17 November 2003 (online)

Abstract

(2S, 5R, 6R)-5,6-Dimethoxy-5,6-dimethyl-[1,4]dioxane-2-carbaldehyde (5) represents a important stable alternative to glyceraldehyde acetonide. Its synthesis on a large scale from inexpensive d-mannitol is described together with other related building blocks.

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Ley, S.V.; Michel, P.; Trapella, C. Org. Lett., in press.