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Synthesis 2003(17): 2629-2631
DOI: 10.1055/s-2003-42431
DOI: 10.1055/s-2003-42431
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A Selective and Mild Oxidation of Primary Amines to Nitriles with Trichloroisocyanuric Acid
Further Information
Received
4 August 2003
Publication Date:
14 October 2003 (online)
Publication History
Publication Date:
14 October 2003 (online)
Abstract
An efficient and highly selective method for the oxidative conversion of primary amines to the corresponding nitriles using trichloroisocyanuric acid in the presence of catalytic TEMPO under mild reaction conditions is described. Other functional groups such as C,C-double bonds, benzyloxy etc. were found to be unaffected under the reaction conditions. This procedure provides a new entry to the synthesis of various aliphatic, aromatic and heterocyclic nitriles in excellent yield.
Key words
trichloroisocyanuric acid - primary amines - nitriles - oxidation
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