Synthesis 2003(16): 2590-2592  
DOI: 10.1055/s-2003-42402
PSP
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Biaryl, Arylamine and Aryl Ketone Compounds Using a Commercially Available Air- and Moisture-Stable Palladium Catalyst

Nicolas Marion, Oscar Navarro, Roy A. Kelly III, Steven P. Nolan*
University of New Orleans, Department of Chemistry, New Orleans, Louisiana, 70148, USA
Fax: +1(504)2806860; e-Mail: [email protected];
Further Information

Publication History

Received 1 August 2003
Publication Date:
29 September 2003 (online)

Abstract

A commercially available palladium complex bearing a N-heterocyclic carbene (NHC) was used in gram-scale synthesis of three compounds, a biaryl, an arylamine and an aryl ketone. The syntheses were performed in catalytic fashion using a Suzuki-Miyaura, a Buchwald-Hartwig and a ketone arylation reaction protocol. These three reactions were carried out using the same palladium pre-catalyst.

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1

Visiting student from the Université Pierre et Marie Curie.

7

Complex 1 is now commercially available from Strem Chemicals Inc.