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Simplified Procedures for 1-Amino-2-propyne and Some Homologues
29 September 2003 (online)
1-Amino-2-propyne has been obtained in good yields by successive solvolysis of propargyl bromide in liquid ammonia, metalation of the dissolved amine with sodamide, and hydrolysis after complete removal of the ammonia by evaporation. Some homologues, RC≡CCH2NH2, have been obtained in fair yields by addition of alkyl bromides to the solution of the sodium derivative of 1-amino-2-propyne.
aminations - amines - alkynes - metalations - alkylations
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