Synlett 2003(14): 2261-2262  
DOI: 10.1055/s-2003-42111
SPOTLIGHT
© Georg Thieme Verlag Stuttgart · New York

Titanium Tetraisopropoxide

Óscar López*
Departamento Química Orgánica, Facultad Química, Universidad Sevilla, Apartado 553, 41071 Sevilla, Spain
e-Mail: osc-lopez@mixmail.com;
Further Information

Publication History

Publication Date:
29 October 2003 (online)

Introduction

Titaniun tetraisopropoxide is a mild Lewis acid that has been extensively used as a catalyst in organic synthesis, specially in those reactions involving asymmetric inductions, [1] such as Sharpless epoxidation, additions to carbonyl compounds, and oxidations; its catalytic activity in asymmetric synthesis is based on the formation of complexes with chiral auxiliaries. [2] Its mild nature enables the use of this catalyst in the presence of some acid-sensitive functional groups, such as acetonides, OTBDMS, and lactams.
Titanium tetraisopropoxide is a non-expensive catalyst, commercially available as a low-melting point solid.

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