Zusammenfassung
Im Hinblick auf die Therapie der Makulopathie scheint die derzeit gängige klinische
Einteilung in die fokale, diffuse und ischämische Makulopathie sinnvoll. Die vorliegende
Zusammenfassung diskutiert den Einsatz therapeutischer Standardverfahren sowie der
in jüngster Zeit zunehmenden chirurgischen und pharmakologischen Möglichkeiten.
Abstract
The current clinical classification into focal, diffuse, and ischaemic maculopathy
is useful with respect to pathomechanism and therapy. This review discusses the value
of standard therapeutical options as well as the recent surgical and pharmacological
approaches.
Schlüsselwörter
Diabetische Retinopathie - diabetische Makulopathie - klinische Einteilung - Lasertherapie
- ILM-Peeling - Triamcinolon
Key words
Diabetic retinopathy - diabetic maculopathy - clinical classification - laser therapy
- ILM peeling - triamcinolone
Literatur
- 1
Aiello L M, Ferris F L.
Photocoagulation for diabetic macular edema.
Arch Ophthalmol.
1987;
105
1163
- 2
Akduman L, Olk R J.
Laser photocoagulation of diabetic macular edema.
Ophthalmic Surg Lasers.
1997;
28
387-408
- 3
Antonetti D A, Wolpert E B, DeMaio L, Harhaj N S, Scaduto R C.
Hydrocortisone decreases retinal endothelial cell water and solute flux coincident
with increased content and decreased phosphorylation of occludin.
J Neurochem.
2002;
80
667-677
- 4
Bailey C C, Sparrow J M, Grey R H, Cheng H.
The National Diabetic Retinopathy Laser Treatment Audit. III. Clinical outcomes.
Eye.
1999;
13
151-159
- 5 Bertram B, Arens C DH.
Leitlinie Nr. 20: Diabetische Retinopathie. In: Bertram B, Arens CDM (Hrsg) Praxisorientierte Handlungsleitlinien für Diagnose
und Therapie in der Augenheilkunde. Düsseldorf; Berufsverband der Augenärzte Deutschlands
1998
- 6
Blankenship G W.
Diabetic macular edema and argon laser photocoagulation: a prospective randomized
study.
Ophthalmology.
1979;
86
69-78
- 7
Bresnick G H, Venecia G de, Myers F L, Harris J A, Davis M D.
Retinal ischemia in diabetic retinopathy.
Arch Ophthalmol.
1975;
93
1300-1310
- 8
Bresnick G H.
Diabetic macular edema. A review.
Ophthalmology.
1986;
93
989-997
- 9
Bresnick G H.
Diabetic maculopathy. A critical review highlighting diffuse macular edema.
Ophthalmology.
1983;
90
1301-1317
- 10
Caird F I, Hutchinson M, Pirie A.
Cataract extraction and diabetes.
Br J Ophthalmol.
1965;
49
466-471
- 11
Cardillo Piccolino F, Zingirian M, Mosci C.
Classification of proliferative diabetic retinopathy.
Graefes Arch Clin Exp Ophthalmol.
1987;
225
245-250
- 12
Early Treatment Diabetic Retinopathy Study Research Group .
Early photocoagulation for diabetic retinopathy. ETDRS report number 9.
Ophthalmology.
1991;
98
766-785
- 13
Fong D S, Segal P P, Myers F, Ferris F L, Hubbard L D, Davis M D.
Subretinal fibrosis in diabetic macular edema. ETDRS report 23. Early Treatment Diabetic
Retinopathy Study Research Group.
Arch Ophthalmol.
1997;
115
873-877
- 14
Gandorfer A, Messmer E M, Ulbig M W, Kampik A.
Resolution of diabetic macular edema after surgical removal of posterior hyaloid and
the inner limiting membrane.
Retina.
2000;
20
126-133
- 15
Garner A.
Histopathology of diabetic retinopathy in man.
Eye.
1993;
7
250-253
- 16 Global Diabetic Retinopathy Project Group .International clinical diabetic macular
edema disease severity scale. 2002
- 17
Grey R H.
The treatment of diabetic maculopathy by argon laser photocoagulation.
Trans Ophthalmol Soc U K.
1986;
105
424-429
- 18 Hammes H P, Bertram B, Bornfeld N, Gandjour A, Parandeh-Shab F, Danne D, Kroll P,
Lemmen K D, Look D.
Diagnostik, Therapie und Verlaufskontrolle der diabetischen Retinopathie und Makulopathie. In: Scherbaum WA, Lauterbach KW, Renner R (Hrsg) Evidenzbasierte Diabetes-Leitlinien
DDG. 1. Auflage. Deutsche Diabetes-Gesellschaft 2000
- 19
The Diabetic Retinopathy Study Research Group .
Indications for photocoagulation treatment of diabetic retinopathy: Diabetic Retinopathy
Study Report no. 14.
Int Ophthalmol Clin.
1987;
27
239-253
- 20
Isenberg S J, Apt L, Yoshimori R, Khwarg S.
Chemical preparation of the eye in ophthalmic surgery. IV. Comparison of povidone-iodine
on the conjunctiva with a prophylactic antibiotic.
Arch Ophthalmol.
1985;
103
1340-1342
- 21
Jaffe G J, Burton T C.
Progression of nonproliferative diabetic retinopathy following cataract extraction.
Arch Ophthalmol.
1988;
106
745-749
- 22
Jonas J B, Kreissig I, Sofker A, Degenring R F.
Intravitreal injection of triamcinolone for diffuse diabetic macular edema.
Arch Ophthalmol.
2003;
121
57-61
- 23
Jonas J B, Sofker A.
Intraocular injection of crystalline cortisone as adjunctive treatment of diabetic
macular edema.
Am J Ophthalmol.
2001;
132
425-427
- 24
Kadonosono K, Itoh N, Ohno S.
Perifoveal microcirculation before and after vitrectomy for diabetic cystoid macular
edema.
Am J Ophthalmol.
2000;
130
740-744
- 25
Klein R, Klein B E, Moss S E, Davis M D, DeMets D L.
The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edema.
Ophthalmology.
1984;
91
1464-1474
- 26
Klein R, Klein B E, Moss S E.
Visual impairment in diabetes.
Ophthalmology.
1984;
91
1-9
- 27
Ladas I D, Theodossiadis G P.
Long-term effectiveness of modified grid laser photocoagulation for diffuse diabetic
macular edema.
Acta Ophthalmol (Copenh).
1993;
71
393-397
- 28
Lee C M, Olk R J.
Modified grid laser photocoagulation for diffuse diabetic macular edema. Long-term
visual results.
Ophthalmology.
1991;
98
1594-1602
- 29 Lemmen K D, Ulbig M W, Bornfeld N, Bertram B, Gerke E H. Initiativgruppe Früherkennung
diabetischer Augenerkrankungen: Stadieneinteilung und Therapie der diabetischen Retinopathie
und Makulopathie, Report No. 3. Heidelberg; Kaden 2001
- 30
Martidis A, Duker J S, Greenberg P B, Rogers A H, Puliafito C A, Reichel E. et al
.
Intravitreal triamcinolone for refractory diabetic macular edema.
Ophthalmology.
2002;
109
920-927
- 31
McDonald H R, Schatz H.
Macular edema following panretinal photocoagulation.
Retina.
1985;
5
5-10
- 32
McNaught E I, Foulds W S, Allan D.
Grid photocoagulation improves reading ability in diffuse diabetic macular oedema.
Eye.
1988;
2
288-296
- 33
Meyers S M.
Macular edema after scatter laser photocoagulation for proliferative diabetic retinopathy.
Am J Ophthalmol.
1980;
90
210-216
- 34
Olk R J.
Argon green (514 nm) versus krypton red (647 nm) modified grid laser photocoagulation
for diffuse diabetic macular edema.
Ophthalmology.
1990;
97
1101-1112; discussion 1112 - 1113
- 35
Olk R J.
Modified grid argon (blue-green) laser photocoagulation for diffuse diabetic macular
edema.
Ophthalmology.
1986;
93
938-950
- 36
Early Treatment Diabetic Retinopathy Study research group .
Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy
Study report number 1.
Arch Ophthalmol.
1985;
103
1796-1806
- 37
Early Treatment Diabetic Retinopathy Study Research Group .
Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy
Study Report no. 4.
Int Ophthalmol Clin.
1987;
27
265-272
- 38
Schatz H, Atienza D, McDonald H R, Johnson R N.
Severe diabetic retinopathy after cataract surgery.
Am J Ophthalmol.
1994;
117
314-321
- 39
Schatz H, Madeira D, McDonald H R, Johnson R N.
Progressive enlargement of laser scars following grid laser photocoagulation for diffuse
diabetic macular edema.
Arch Ophthalmol.
1991;
109
1549-1551
- 40
Straatsma B R, Pettit T H, Wheeler N, Miyamasu W.
Diabetes mellitus and intraocular lens implantation.
Ophthalmology.
1983;
90
336-343
- 41
Tachi N, Ogino N.
Long-term follow-up of grid photocoagulation for diffuse macular edema associated
with diabetic retinopathy.
Folia Ophthalmol Jpn.
1996;
47
1252-1256
- 42
Ballegooie E van, Everdingen J J van.
CBO guidelines on diagnosis, treatment, and prevention of complication in diabetes
mellitus: retinopathy, foot ulcers, nephropathy and cardiovascular diseases. Dutch
Institute for Quality Assurance.
Ned Tijdschr Geneeskd.
2000;
144
413-418
- 43
Wallow I H.
Repair of the pigment epithelial barrier following photocoagulation.
Arch Ophthalmol.
1984;
102
126-135
- 44
Watanabe M, Oshima Y, Emi K.
Optical cross-sectional observation of resolved diabetic macular edema associated
with vitreomacular separation.
Am J Ophthalmol.
2000;
129
264-267
- 45
Weiter J J, Zuckerman R.
The influence of the photoreceptor-RPE complex on the inner retina. An explanation
for the beneficial effects of photocoagulation.
Ophthalmology.
1980;
87
1133-1139
- 46
Whitelocke R A, Kearns M, Blach R K, Hamilton A M.
The diabetic maculopathies.
Trans Ophthalmol Soc U K.
1979;
99
314-320
- 47
Zander E, Herfurth S, Bohl B, Heinke P, Herrmann U, Kohnert K D. et al .
Maculopathy in patients with diabetes mellitus type 1 and type 2: associations with
risk factors.
Br J Ophthalmol.
2000;
84
871-876
PD Dr. Antonia M. Joussen
Abteilung für Netzhaut- und Glaskörperchirurgie · Zentrum für Augenheilkunde
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Email: JoussenA@aol.com
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