Molecular Sieve (MS 4A) Promoted Cyclocondensation of Hindered, Aromatic Nitrile Oxides and Cyclic Diketones under Mild Conditions
22 September 2003 (online)
Molecular sieves (MS 4A) serve as efficient promoters for the cyclocondensation of stable, hindered nitrile oxides and a variety of cyclic diketones to afford fused isoxazoles in good yield. The operational simplicity and remarkably mild reaction conditions compliment our amine-promoted cyclocondensation conditions and demonstrate broad substrate scope.
cycloadditions - ketones - condensation - isoxazoles - molecular sieves