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Synlett 2003(12): 1853-1855  
DOI: 10.1055/s-2003-41409
LETTER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Acetoxy Stabilised Indolequinones as Precursors to Model Eumelanin Polymers

Sov Atkinson, Paul Meredith*
Department of Physics, Centre for Biophotonics and Laser Science, University of Queensland, 4072, Brisbane, Queensland, Australia
Fax: +61(7)33651242; e-Mail: meredith@physics.uq.edu.au ;
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Publication History

Received 2 May 2003
Publication Date:
28 August 2003 (online)

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Abstract

We report an efficient synthetic route to obtaining a stable analogue of 5,6-dihydroxyindole. These analogues can be used to build controlled composition model melanin biopolymers for solid state and spectroscopic studies of this important biomolecule.

Key words

5,6-dihydroxyindole - 5,6-diacetoxyindole - melanin biopolymers - melanin precursors - nitration of activated aromatic compound