Subscribe to RSS
DOI: 10.1055/s-2003-41103
Kardiovaskuläre Risikofaktoren bei Frauen
Cardiovascular risk factors in womenPublication History
eingereicht: 10.1.2003
akzeptiert: 29.4.2003
Publication Date:
01 August 2003 (online)

Wir wissen heute, dass es eine Reihe geschlechtsspezifischer Unterschiede hinsichtlich Entstehung, Klinik, Verlauf und Prognose der koronaren Herzkrankheit (KHK) gibt [2]. Bei Frauen entwickelt sich die KHK circa 10 - 15 Jahre später als beim Mann, das Risiko steigt - vermutlich durch Wegfall der endogenen Steroidhormone - nach der Menopause an. Von besonderer Bedeutung ist die Tatsache, dass bei Frauen in der Regel zwar die gleichen Faktoren wie bei Männern atherogen wirken, diese aber in ihrer Wertigkeit zum Teil stark differieren: So ist bei Frauen der Diabetes mellitus mit einem zwei- bis dreifach höheren koronaren Risiko als bei Männern assoziiert. Eine bessere Kenntnis der Unterschiede in der atherogenen Potenz der Risikofaktoren ist somit für eine optimale geschlechtsspezifische Prävention und Therapie entscheidend [51]. Hier sollen die frauenspezifischen Besonderheiten im koronaren Risikofaktorprofil aufgezeigt, analysiert und in ihrer Wertigkeit dargestellt werden.
Literatur
- 1
Anderson K M, Castelli W P, Levy D.
Cholesterol and mortality: 30 years of follow-up from the
Framingham
study.
JAMA.
1987;
257
2176-2180
Reference Ris Wihthout Link
- 2
Arbogast A, Sechtem U.
Diagnose der Herzkrankheit bei Frauen.
Dtsch Med
Wochenschr.
2003;
128
97-102
Reference Ris Wihthout Link
- 3
Bankier B, Littman A B.
Psychiatric disorders and coronary heart disease in women
- a still neglected topic: review of the literature from 1971 to
2000.
Psychother
Psychosom.
2002;
71
133-140
Reference Ris Wihthout Link
- 4
Castelli W P.
Epidemiology of triglycerides: a view from
Framingham.
Am J
Cardiol.
1992;
70
3H-9H
Reference Ris Wihthout Link
- 5
Christen W G, Ajani U A, Glynn R J, Hennekens C H.
Blood levels of homocysteine and increased risk of
cardiovascular disease: causal or casual.
Arch Intern
Med.
2000;
160
422-434
Reference Ris Wihthout Link
- 6
Corti M C, Guralnik J M, Salive M E. et al .
HDL cholesterol predicts coronary heart disease mortality in
older
persons.
JAMA.
1995;
274
539-544
Reference Ris Wihthout Link
- 7
Dierkes J, Jeckel A, Ambrosch A, Westphal S, Luley C, Boeing H.
Factors explaining the difference of total homocyst(e)ine
between men and women in the European Investigation into Cancer and Nutrition
Potsdam
Study.
Metabolism.
2001;
50
640-645
Reference Ris Wihthout Link
- 8
Dorn J M, Schisterman E F, Winkelstein W, Trevisan M.
Body mass index and mortality in a general population sample
of men and women. The Buffalo Health Study.
Am J
Epidemiol.
1997;
146
919-931
Reference Ris Wihthout Link
- 9
Eaker E D.
Psychosocial risk factors for coronary heart disease in
women.
Cardiol
Clin.
1998;
16
103-111
Reference Ris Wihthout Link
- 10
Eriksson M, Egberg N, Wamala S, Orth-Gomer K, Mittleman M A, Schenck-Gustafsson K.
Relationship between plasma fibrinogen and coronary heart
disease in women.
Arterioscler Thromb Vasc
Biol.
1999;
19
67-72
Reference Ris Wihthout Link
- 11
Folsom A R, Kushi L H, Anderson K E. et al .
Association of general and abdominal obesity with multiple
health outcomes in older women: the Iowa Women’s Health
Study.
Arch Intern
Med.
2000;
160
2117-2128
Reference Ris Wihthout Link
- 12
Folsom A R, Nieto F J, McGovern P G. et al .
Prospective study of coronary heart disease incidence in
relation to fasting total homocysteine, related genetic polymorphisms, and B
vitamines: the Atherosclerosis Risk in Communities (ARIC)
study.
Circulation.
1998;
98
204-210
Reference Ris Wihthout Link
- 13
Folsom A R, Wu K K, Rasmussen M, Chambless L E, Aleksic N, Nieto F J.
Determinants of population changes in fibrinogen and factor
VII over 6 years. The Atherosclerosis Risk in Communities (ARIC)
Study.
Arterioscler Thromb Vasc
Biol.
2000;
20
601-606
Reference Ris Wihthout Link
- 14
Folsom A R, Wu K K, Rosamond W D, Sharrett A R, Chambless L E.
Prospective study of hemostatic factors and incidence of
coronary heart disease: the Atherosclerosis Risk in Communities (ARIC)
Study.
Circulation.
1997;
96
1102-1108
Reference Ris Wihthout Link
- 15
Friedlander Y, Arbogast P, Schwartz S M. et al .
Family history as a risk factor for early onset myocardial
infarction in young
women.
Atherosclerosis.
2001;
156
201-207
Reference Ris Wihthout Link
- 16
Garber A M, Browner W S, Hulley S B.
Cholesterol screening in asymptomatic adults,
revisited.
Ann Intern
Med.
1996;
124
518-531
Reference Ris Wihthout Link
- 17
Gohlke-Bärwolf C.
Coronary artery disease - is menopause a risk
factor?.
Basic Res
Cardiol.
2000;
95
I/77-I/83
Reference Ris Wihthout Link
- 18
Gordon D J, Probstfield J L, Garrison R J. et al .
High-density lipoprotein cholesterol and cardiovascular
disease: four prospective American
studies.
Circulation.
1989;
79
8-15
Reference Ris Wihthout Link
- 19
Grady D, Herrington D, Bittner V. et al. HERS Research Group .
Cardiovascular disease outcomes during 6.8 years of hormone
therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS
II).
JAMA.
2002;
288
49-57
Reference Ris Wihthout Link
- 20
Hahmann H W, Schätzer-Klotz D, Bunte T, Becker D, Schieffer H J.
The significance of high levels of lipoprotein (a) compared
with established risk factors in premature coronary artery disease: differences
between men and
women.
Atherosclerosis.
1999;
144
221-228
Reference Ris Wihthout Link
- 21
Haynes S G, Feinleib M, Kannel W B.
The relationship of psychosocial factors to coronary heart
disease in the Framingham Study. III. Eight-year incidence of coronary heart
disease.
Am J
Epidemiol.
1980;
111
37-58
Reference Ris Wihthout Link
- 22
Hokanson J E, Austin M A.
Plasma triglyceride level is a risk factor for cardiovascular
disease independent of high-density lipoprotein cholesterol level: a
meta-analysis of population-based prospective studies.
J Cardiovasc
Risk.
1996;
3
213-219
Reference Ris Wihthout Link
- 23
Hu F B, Stampfer M J, Manson J E. et al .
Trends in the incidence of coronary heart disease and changes
in diet and lifestyle in women.
N Engl J
Med.
2000;
343
530-537
Reference Ris Wihthout Link
- 24
Hu F B, Stampfer M J, Solomon C. et al .
Physical activity and risk for cardiovascular events in
diabetic women.
Ann Intern
Med.
2001;
134
96-105
Reference Ris Wihthout Link
- 25
Kannel W B.
Risk stratification in hypertension: new insights from the
Framingham Study.
Am J
Hypertens.
2000;
13
3S-10S
Reference Ris Wihthout Link
- 26
Kuulasmaa K, Tunstall-Pedoe H, Dobson A. et al., for the MONICA Project .
Estimation of contribution of changes in classic risk factors
to trends in coronary event-rates across the WHO MONICA Project
populations.
Lancet.
2000;
355
675-687
Reference Ris Wihthout Link
- 27
Laakso M, Ronnemaa T, Lehto S, Puukka P, Kallio V, Pyorala K.
Does NIDDM increase the risk for coronary heart disease
similarly in both low- and high-risk
populations?.
Diabetologia.
1995;
38
487-493
Reference Ris Wihthout Link
- 28
Laing S P, Swerdlow A J, Slater S D. et al .
The British Diabetic Association Cohort Study, II:
cause-specific mortality in patients with insulin-treated diabetes
mellitus.
Diabet
Med.
1999;
16
466-471
Reference Ris Wihthout Link
- 29
Lapidus L, Bengtsson C, Lindquist O, Sigurdsson J A, Ryboe E.
Triglycerides - main lipid risk factor for
cardiovascular disease in women?.
Acta Med
Scand.
1985;
217
481-489
Reference Ris Wihthout Link
- 30
Lee I M, Rexrode K M, Cook N R, Manson J E, Buring J E.
Physical activity and coronary heart disease in women: Is
„no pain, no gain“
passé?.
JAMA.
2001;
285
1447-1454
Reference Ris Wihthout Link
- 31
Lee W L, Cheung A M, Cape D, Zinman B.
Impact of diabetes on coronary artery disease in women and
men: a meta-analysis of prospective studies.
Diabetes
Care.
2000;
23
962-968
Reference Ris Wihthout Link
- 32
Manolio T A, Pearson T A, Wenger N K, Barrett-Connor E, Payne G H, Harlan W R.
Cholesterol and heart disease in older persons and women:
review of an NHLBI workshop.
Ann
Epidemiol.
1992;
2
161-176
Reference Ris Wihthout Link
- 33
Mansfield M W, Heywood D M, Grant P J.
Sex differences in coagulation and fibrinolysis in white
subjects with non-insulin-dependent diabetes mellitus.
Arterioscler
Thromb Vasc
Res.
1996;
16
160-164
Reference Ris Wihthout Link
- 34
Manson J AE, Hu F B, Rich-Edwards J W. et al .
A prospective study of walking as compared with vigorous
exercise in the prevention of coronary heart disease in women.
N Engl
J
Med.
1999;
341
650-658
Reference Ris Wihthout Link
- 35
Maron D J.
The epidemiology of low levels of high-density lipoprotein
cholesterol in patients with and without coronary artery disease.
Am
J
Cardiol.
2000;
86
11L-14L
Reference Ris Wihthout Link
- 36
Meade T W, Ruddock V, Stirling Y, Chakrabarti R, Miller G J.
Fibrinolytic activity, clotting factors, and long-term
incidence of ischaemic heart disease in the Northwick Park Heart
Study.
Lancet.
1993;
342
1076-1079
Reference Ris Wihthout Link
- 37
Nanchahal K, Ashton W D, Wood D A.
Association between blood pressure, the treatment of
hypertension, and cardiovascular risk factors in women.
J
Hypertens.
2000;
18
833-841
Reference Ris Wihthout Link
- 38
Orth-Gomer K, Horsten M, Wamala S P. et al .
Social relations and extent and severity of coronary artery
disease: The Stockholm Female Coronary Risk Study.
Eur Heart
J.
1998;
19
1648-1656
Reference Ris Wihthout Link
- 39
Orth-Gomer K, Mittleman M A, Schenck-Gustafsson K. et al .
Lipoprotein (a) as a determinant of coronary heart disease in
young
women.
Circulation.
1997;
95
329-334
Reference Ris Wihthout Link
- 40
Orth-Gomer K, Wamala S P, Horsten M, Schenck-Gustafsson K, Schneiderman N, Mittleman M A.
Marital stress worsens prognosis in women with coronary heart
disease: The Stockholm Female Coronary Risk
Study.
JAMA.
2000;
284
3008-3014
Reference Ris Wihthout Link
- 41
Ossei-Gerning N, Wilson I J, Grant P J.
Sex differences in coagulation and fibrinolysis in subjects
with coronary artery disease.
Thromb
Haemost.
1998;
79
736-740
Reference Ris Wihthout Link
- 42
Poulter R. for the WHO Collaborative Study of Cardiovascular Disease
and Steroid Hormone Contraception .
Acute myocardial infarction and combined oral contraceptives:
results of an international multicentre case-control
study.
Lancet.
1997;
349
1202-1209
Reference Ris Wihthout Link
- 43
Ridker P M, Buring J E, Shih H, Matias M, Hennekens C H.
Prospective study of C-reactive protein and the risk of
future cardiovascular events among apparently healthy
women.
Circulation.
1998;
98
731-733
Reference Ris Wihthout Link
- 44
Ridker P M, Hennekens C H, Buring J E, Rifai N.
C-reactive protein and other markers of inflammation in the
prediction of cardiovascular disease in women.
N Engl J
Med.
2000;
342
836-843
Reference Ris Wihthout Link
- 45
Ridker P M, Manson J E, Buring J E, Shih J, Matias M, Hennekens C H.
Homocyst(e)ine and risk of cardiovascular disease among
postmenopausal
women.
JAMA.
1999;
281
1817-1821
Reference Ris Wihthout Link
- 46
Rossouw J E, Anderson G L, Prentice R L. et al. Writing Group for the Women’s Health
Initiative Investigators .
Risks and benefits of estrogen plus progestin in healthy
postmenopausal women: principal results From the Women’s Health
Initiative randomized controlled
trial.
JAMA.
2002;
288
321-333
Reference Ris Wihthout Link
- 47
Rozanski A, Blumenthal J A, Kaplan J.
Impact of psychological factors on the pathogenesis of
cardiovascular disease and implication for
therapy.
Circulation.
1999;
99
2192-2217
Reference Ris Wihthout Link
- 48
Schulte H, von Eckardstein A, Cullen P, Assmann G.
Obesity and cardiovascular
risk.
Herz.
2001;
26
170-177
Reference Ris Wihthout Link
- 49
Sesso H D, Lee I M, Gaziano J M, Rexrode K M, Glynn R J, Buring J E.
Maternal and paternal history of myocardial infarction and
risk of cardiovascular disease in men and
women.
Circulation.
2001;
104
393-398
Reference Ris Wihthout Link
- 50
Stampfer M J, Hu F B, Manson J E, Rimm E B, Willett W C.
Primary prevention of coronary heart disease in women through
diet and lifestyle.
N Engl J
Med.
2000;
343
16-22
Reference Ris Wihthout Link
- 51
Stangl V, Baumann G, Stangl K.
Coronary atherogenic risk factors in women.
Eur
Heart
J.
2002;
23
1738-1752
Reference Ris Wihthout Link
- 52
The writing group for the PEPI Trial .
Effects of estrogen or estrogen/progestin regimens on
heart disease risk factors in postmenopausal women: the Postmenopausal
Estrogen/Progestin Interventions (PEPI)
trial.
JAMA.
1995;
273
199-208
Reference Ris Wihthout Link
- 53
Verhoef P.
Hyperhomocysteinemia and risk of vascular disease in
women.
Semin Thromb
Hemost.
2000;
26
325-334
Reference Ris Wihthout Link
- 54
Wagenknecht L E, Craven T E, Preisser J S, Manolio T A, Winders S, Hulley S B.
Ten-year trends in cigarette smoking among young adults,
1986 - 1996: The CARDIA Study.
Ann
Epidemiol.
1998;
8
301-307
Reference Ris Wihthout Link
- 55
Wamala S P, Mittleman M A, Horsten M, Schenck-Gustafsson K, Orth-Gomer K.
Job stress and the occupational gradient in coronary heart
disease in women: The Stockholm Female Coronary Risk Study.
Soc Sci
Med.
2000;
51
481-489
Reference Ris Wihthout Link
- 56
Welch G N, Loscalzo J.
Homocysteine and atherothrombosis.
N Engl J
Med.
1998;
338
1042-1050
Reference Ris Wihthout Link
- 57
Welty F K.
Cardiovascular disease and dsylipidemia in
women.
Arch Intern
Med.
2001;
161
514-522
Reference Ris Wihthout Link
- 58
Willett W C, Manson J E, Stampfer M J. et al .
Weight, weight change, and coronary heart disease in
women.
JAMA.
1995;
273
461-465
Reference Ris Wihthout Link
- 59
Woodward M, Lowe G DO, Rumley A, Tunstall-Pedoe H.
Fibrinogen as a risk factor for coronary heart disease and
mortality in middle-aged men and women.
Eur Heart
J.
1998;
19
55-62
Reference Ris Wihthout Link
Priv.-Doz. Dr. med. Verena Stangl
Charité der Humboldt-Universität. Campus Mitte, Med.
Klinik mit Schwerpunkt Kardiologie, Angiologie, Pneumologie
Schumannstraße 21/21
10117 Berlin
Phone: +49/030/450513153
Fax: +49/030/450513932
Email: verena.stangl@charite.de