Convenient N-Formylation of Secondary Amines: KF-Al₂O₃-Promoted Synthesis of Formamide Derivatives via Dichlorocarbene Generated from Chloroform

Abstract

The treatment of secondary amines with chloroform in the presence of KF-Al₂O₃ in acetonitrile brought about highly facile and efficient N-formylation to give the corresponding formamides in good to excellent yields. The N-formylation reaction not only involves mild conditions, simple operations and high yields but high chemoselectivity as well.

Keywords

potassium fluoride - formylation - amines - amides - carbenes

References

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