A Convenient Synthesis of N-Acylpyrroles from Primary Aromatic Amides

Anil R. Ekkati; Dallas K. Bates

doi:10.1055/s-2003-41020

SHORTPAPER

A Convenient Synthesis of N-Acylpyrroles from Primary Aromatic Amides

Anil R. Ekkati, Dallas K. Bates*
Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA
Fax: +1(906)4872061; e-Mail: dbates@mtu.edu;

Abstract

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Abstract

Synthesis of N-acylpyrroles in 45-85% isolated yield from primary aromatic amides and excess 2,5-dimethoxytetrahydrofuran in presence of one equivalent of thionyl chloride is reported. This method has several advantages including short reaction times, mild reaction conditions, and easy workup. The technique works particularly well for deactivated aromatic amides.

Key words

N-acylpyrroles - primary amides - condensation - 2,5-dimethoxytertahydrofuran

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References

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