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Synlett 2003(9): 1344-1348
DOI: 10.1055/s-2003-40355
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Deuterium-labeled 2′-Hydroxypyridoxol

Nisar Ullah, Johannes Zeidler, Ian D. Spenser*
Department of Chemistry, McMaster University, Hamilton, Ontario L8S 4M1, Canada
Fax: +1(905)5222509; e-Mail: spenser@mcmaster.ca;
Further Information

Publication History

Received 25 November 2002
Publication Date:
30 June 2003 (online)

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Abstract

The preparation of [5′,5′-2H2]- and [2′,2′,5′,5′-2H4]-2′-hydroxypyridoxol, as well as of [5′,5′-2H2]-4-pyridoxic acid, starting from 3,4′-O-isopropylidenepyridoxol, is described. The labeled compounds were employed in an investigation of the biosynthesis of Vitamins B1 and B6.

Key words

deuterium-labeling - vitamins B1 and B6 - biosynthesis - 2′-hydroxypyridoxine - deuterium NMR

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