Synlett 2003(7): 1025-1027
DOI: 10.1055/s-2003-39290
© Georg Thieme Verlag Stuttgart ˙ New York

A Short Preparation of an Advanced Intermediate for Lactacystin Synthesis: The Complete Carbon Skeleton of Clasto-Lactacystin Dihydroxyacid

Philip C. Bulman Page*, David C. Leach, Colin M. Hayman, A. Sazali Hamzah, Steven M. Allin, Vickie McKee
Department of Chemistry, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK
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Further Information

Publication History

Received 26 March 2003
Publication Date:
20 May 2003 (online)


An advanced intermediate 22 for lactacystin synthesis, containing the full carbon skeleton of the pyrrolidinone component, has been achieved in four steps from a protected glycine ester.