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Synlett 2003(6): 0833-0836
DOI: 10.1055/s-2003-38740
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-HetPHOX Complexes for the Catalytic Asymmetric Hydrogenation of Olefins and Imines

Pier Giorgio Cozzi*a, Frederik Mengesb, Stefan Kaiserb
a Dipartimento di Chimica , ‘G. Ciamician’, Via Selmi 2, 40126, Bologna, Italy
Fax: +39(51)2099456; e-Mail: pgcozzi@ciam.unibo.it;
b Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland
Further Information

Publication History

Received 19 February 2003
Publication Date:
17 April 2003 (online)

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Abstract

Heterocyclic phosphino oxazolines derived from thiophene and benzo[b]thiophene (HetPHOX) form highly active iridium complexes for the enantioselective hydrogenation of olefins and imines.

Key words

hydrogenation - asymmetric catalysis - ligands - iridium - alkenes

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8

Single crystals of complex 6c were obtained by layering a chloroform solution with pentane. Crystallographic data have been deposited under CCDC 203958.

9

Smidt, S. P.; Mukherjee, P.; Pfaltz, A.; Neuburger, M., unpublished results.