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Synlett 2003(4): 0561-0563
DOI: 10.1055/s-2003-37527
LETTER
© Georg Thieme Verlag Stuttgart · New York

Optically Active Lithium-Alkoxide Catalyzed Asymmetric Reduction of Imines with Trimethoxyhydrosilane

Hisashi Nishikori, Ritsuko Yoshihara, Akira Hosomi*
Department of Chemistry, Graduate School of Pure and Applied Science, University of Tsukuba, CREST JST (Japan Science and Technology), Tsukuba, Ibaraki 305-8571, Japan
Fax: +81(298)536503; e-Mail: hosomi@chem.tsukuba.ac.jp;
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Publication History

Received 19 January 2003
Publication Date:
26 February 2003 (online)

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Abstract

Optically active lithium alkoxide catalyzed asymmetric reduction of imines with trimethoxhydroysilane in moderate enantioselectivity (up to 72% ee).

Key words

asymmetric reduction - lithium alkoxide - imine - solvent effect

    References

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8

We have already found that diastereoselectivity was switched by selection of solvent in the reduction of α,β-epoxyketones. See ref. [4b]