Synlett 2003(4): 0473-0476
DOI: 10.1055/s-2003-37520
LETTER
© Georg Thieme Verlag Stuttgart · New York

Removable Phosphine Reagents for the Mitsunobu Reaction

Christiane Yoakim*, I. Guse, J. A. O’Meara, B. Thavonekham
Boehringer Ingelheim (Canada) Ltd., R&D, 2100 Cunard Street; Laval (Québec), H7S 2G5, Canada
e-Mail: [email protected];
Further Information

Publication History

Received 26 November 2002
Publication Date:
26 February 2003 (online)

Abstract

We have developed a novel triphenylphosphine replacement for the Mitsunobu reaction. We have demonstrated that 4-diphenylphosphanyl-benzoic acid 2-trimethylsilanyl-ethyl ester (DPPBE) is an efficient reagent and greatly facilitates the isolation of the desired product.

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10

Phosphoric acid (85%) was used as an external reference.