Synlett 2003(4): 0542-0546
DOI: 10.1055/s-2003-37512
LETTER
© Georg Thieme Verlag Stuttgart · New York

One-pot Sequence for the Decarboxylation of α-Amino Acids

Gilles Laval, Bernard T. Golding*
School of Natural Sciences - Chemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, UK
Fax: +44(191)2226929; e-Mail: b.t.golding@ncl.ac.uk;
Further Information

Publication History

Received 24 January 2003
Publication Date:
26 February 2003 (online)

Abstract

Treatment of an α-amino acid with N-bromosuccinimide in water at pH 5 or in an alcoholic-aqueous ammonium chloride mixture, followed by addition of nickel(II) chloride and sodium borohydride, effected an overall decarboxylation via an intermediate nitrile to afford the corresponding amine in good yield.