Stereoselective Syntheses of (E)-α,β-Dehydroamino Acids and (E)-α,β-De­hydropeptides by Stereospecific Dehydration with 1-Ethyl-3-(3-dimethyl­aminopropyl)carbodiimide (EDC)

Abstract

Highly stereoselective syntheses of (E)-α,β-dehydroamino acids and (E)-α,β-dehydropeptides have been achieved in good yields by stereospecific dehydration of threo-β-hydroxy-α-amino acid derivatives using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and CuCl₂.

Key words

α,β-dehydroamino acids - α,β-dehydropeptides - stereospecific­ dehydration - syn-elimination - carbodiimide.

References

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15

In the case of CuCl similar result (90% yield, E:Z = 96:4) was obtained.