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Synthesis 2003(1): 0112-0116
DOI: 10.1055/s-2003-36251
PAPER
© Georg Thieme Verlag Stuttgart · New York

Practical and Scaleable Syntheses of 3-Hydroxythiophenol

Mingbao Zhang*1, David Ryckman, Guohua Chen, Eric MacMillan, Jason Duquette
Pharmaceutical and Agricultural Fine Chemicals Division, AlliedSignal Specialty Chemicals, Morristown, NJ 07960, USA
e-Mail: mingbao.zhang.b@bayer.com;
Further Information

Publication History

Received 27 June 2002
Publication Date:
18 December 2002 (online)

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Abstract

3-Hydroxythiophenol is a versatile intermediate for the synthesis of medicinal and heterocyclic compounds. Two novel and practical syntheses of 3-hydroxythiophenol are achieved using readily available and inexpensive starting materials. An overall cost comparison of these syntheses is also given.

Key words

3-hydroxythiophenol - Grignard reactions - diazo compounds - sulfur - practical synthesis

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1

Author for correspondence. Current address: Department of Chemistry, Bayer Research Center, Pharmaceutical Division, 400 Morgan Lane, West Haven, CT 06516. E-mail: mingbao.zhang.b@bayer.com; telephone +1(203)8125906; fax +1(203)8163505

10

No attempt was made to assess the stability and energy of decomposition of the di-diazonium salt intermediate.