Synlett 2002(12): 2125-2126
DOI: 10.1055/s-2002-35586
SPOTLIGHT
© Georg Thieme Verlag Stuttgart · New York

Tetra Butyl Ammonium Fluoride: TBAF

Majeti Bharat Kumar*
e-Mail: mbkumar@iict.ap.nic.in;
Further Information

Publication History

Publication Date:
20 November 2002 (online)

Tetra butyl ammonium fluoride (TBAF) has been used widely as a reagent for the efficient cleavage of various silyl protecting groups from O-silylated nucleosides [1] [2] and pyrophosphates, [3] as well as N-silyl, [4] and S- silyl derivatives. [5] These reactions are carried out under very mild conditions in excellent yields.

Preparation: Aqueous HF is passed through an amberlite IRA 410 OH column, followed by an aqueous solution of tetra-butylammonium bromide. After the resin is washed with H2O, the combined H2O fractions are repeatedly evaporated until no water is present. TBAF is collected as an oil in quantitative yield.