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DOI: 10.1055/s-2002-34943
Diagnostik und Therapie der akuten myeloischen Leukämie
Diagnostics and therapy of acute myeloid leukemiaPublication History
eingereicht: 16.7.2002
akzeptiert: 22.9.2002
Publication Date:
18 October 2002 (online)

Die Untersuchungen zur Diagnosesicherung und Subklassifizierung der akuten myeloischen Leukämie (AML) beinhalten heute eine Kombination aus zytomorphologischen sowie zyto- und molekulargenetischen Untersuchungen. Diese sind die Voraussetzung für eine adäquate Therapie, die vorgenommen werden sollte, um den Therapiestandard sicherzustellen und um die therapeutischen Möglichkeiten innerhalb klinischer Studien weiter zu verbessern.
Literatur
- 1
Bennett J M, Catovsky D, Daniel M T. et al .
Proposals for
the classification of the acute leukaemias. French- American-British
(FAB) co-operative group.
Br J Haematol.
1976;
33
451-458
MissingFormLabel
- 2 Jaffe E S, Harris N L, Stein H, Vardiman J W. World Health
Organization Classification of Tumours. Pathology and Genetics of
Tumours of Haematopoietic and Lymphoid Tissues. Lyon,
IARC Press 2001
MissingFormLabel
- 3
Haferlach T, Schoch C, Schnittger S, Kern W, Loffler H, Hiddemann W.
Distinct genetic patterns
can be identified in acute monoblastic and acute monocytic leukaemia
(FAB AML M5a and M5b): a study on 124 patients.
Br J Haematol.
2002;
118
426-431
MissingFormLabel
- 4
Haferlach T, Schoch C.
WHO classification of
acute myeloid leukaemia (AML) and the myelodysplastic syndrome (MDS).
Dtsch
Med Wochenschr.
2002;
127
447-450
MissingFormLabel
- 5
Schoch C, Haferlach T, Haase D. et
al .
Patients with de novo acute myeloid leukaemia and
complex karyotype aberrations show a poor prognosis despite intensive
treatment: a study of 90 patients.
Br J Haematol.
2001;
112
118-126
MissingFormLabel
- 6
Grimwade D, Walker H, Oliver F. et al .
The importance of diagnostic cytogenetics
on outcome in AML: analysis of 1,612 patients entered into the MRC
AML 10 trial. The Medical Research Council Adult and Children’s Leukaemia
Working Parties.
Blood.
1998;
92
2322-2333
MissingFormLabel
- 7
Schoch C, Kern W, Krawitz P. et
al .
Dependence of age-specific incidence of acute myeloid
leukemia on karyotype.
Blood.
2001;
98
3500
MissingFormLabel
- 8
Lengfelder E, Reichert A, Schoch C. et al. German AML Cooperative Group .
Double induction
strategy including high dose cytarabine in combination with all-trans
retinoic acid: effects in patients with newly diagnosed acute promyelocytic
leukemia.
Leukemia.
2000;
14
1362-1370
MissingFormLabel
- 9
Ostermann H, Derigs H G, Heussel G. et al .
Sepsis in neutropenia. Standard recommendations
of the Work Group of Infections in Hematology and Oncology of the
German Association for Hematology and Oncology.
Dtsch
Med Wochenschr.
1999;
124
S14-S17
(Suppl 1)
MissingFormLabel
- 10
Buchner T, Hiddemann W, Wormann B. et al .
Double induction strategy for acute myeloid
leukemia: The effect of high-dose cytarabine with mitoxantrone instead
of standard-dose cytarabine with daunorubicin and 6-thioguanine:
A randomized trial by the German AML Cooperative Group.
Blood.
1999;
93
4116-4124
MissingFormLabel
- 11
Kern W, Haferlach T, Schoch C. et al .
Early blast clearance by remission induction
therapy is a major independent prognostic factor for both achievement
of complete remission and long-term outcome in acute myeloid leukemia:
data from the German AML Cooperative Group 1992 Trial.
Blood.
(in press);
MissingFormLabel
- 12
Hiddemann W, Kern W, Schoch C. et
al .
Management of acute myeloid leukemia in elderly
patients.
J Clin Oncol.
1999;
17
3569-3576
MissingFormLabel
- 13
Mayer R J, Davis R B, Schiffer C A. et al. Cancer and Leukemia Group B .
Intensive
postremission chemotherapy in adults with acute myeloid leukemia.
N
Engl J Med.
1994;
331
896-903
MissingFormLabel
- 14
Buchner T, Urbanitz D, Hiddemann W. et al .
Intensified induction and consolidation
with or without maintenance chemotherapy for acute myeloid leukemia
(AML): two multicenter studies of the German AML Cooperative Group.
J
Clin Oncol.
1985;
3
1583-1589
MissingFormLabel
- 15
Cassileth P A, Harrington D P, Appelbaum F R. et al .
Chemotherapy compared
with autologous or allogeneic bone marrow transplantation in the management
of acute myeloid leukemia in first remission (see comments).
N
Engl J Med.
1998;
339
1649-1656
MissingFormLabel
- 16
Kern W, Schoch C, Fonatsch C. et
al .
Therapie der akuten myeloischen Leukämie
bei Patienten im höheren Lebensalter.
Dtsch Med
Wochenschr.
1999;
124
1005-1014
MissingFormLabel
- 17
Leith C P, Kopecky K J, Godwin J. et al. A Southwest Oncology Group study .
Acute
myeloid leukemia in the elderly: assessment of multidrug resistance
(MDR1) and cytogenetics distinguishes biologic subgroups with remarkably
distinct responses to standard chemotherapy.
Blood.
1997;
89
3323-3329
MissingFormLabel
Dr. med. Wolfgang Kern
Klinikum der Universität München-Großhadern, Medizinische
Klinik III
81366 München
Phone: 089/70954986
Fax: 089/70954971
Email: wolfgang.kern@med3.med.uni-muenchen.de