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Synthesis 2002(13): 1903-1911
DOI: 10.1055/s-2002-33918
PAPER
© Georg Thieme Verlag Stuttgart · New York

Stereospecific Synthesis of 3,3-Disubstituted Acrylonitriles by Heck Reaction

Judit Masllorensa, Marcial Moreno-Mañasb, Anna Pla-Quintanaa, Roser Pleixats*b, Anna Roglans*a
Department of Chemistry, Universitat de Girona, 17071-Girona, Spain
Fax: 34(972)418150; e-Mail: anna.roglans@udg.es;
Department of Chemistry, Universitat Autònoma de Barcelona, Cerdanyola, 08193-Barcelona, Spain
Further Information

Publication History

Received 30 April 2002
Publication Date:
09 September 2002 (online)

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Abstract

The coupling reaction of 3-aryl (or heteroaryl) acrylonitriles with several aryl and heteroaryl iodides (Heck reaction) under Jeffery’s conditions has been studied as a concept to synthesize, in a stereospecific manner, trisubstituted olefins.

Key words

arylations - Heck reaction - heterocycles - Palladium catalysis - alkenes

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