Osteosynthesis and Trauma Care 2002; 10(Suppl 1): S22-S24
DOI: 10.1055/s-2002-33830
© Georg Thieme Verlag Stuttgart · New York

The Biocompatibility of a New Bone Glue - First Results of an Experimental Study

C. Heiss1 , P. Pokinskyj2 , N. Hahn1 , S. Wenisch1 , U. Horas1 , O. Kilian1 , B. Nies2 , R. Schnettler1
  • 1Department of Trauma Surgery, Justus-Liebig-Universität Giessen, Giessen, Germany
  • 2Merck Biomaterial GmbH, Darmstadt, Germany
Further Information

Publication History

Publication Date:
11 September 2002 (online)


The aim of this experimental study was to verify the biocompatibility of a new bone glue in a fracture model in rabbits. The fracture healing after the glue application and osseointegration were to be analyzed through histological and radiological invastigations. 36 rabbits were operated unifemoral and observed over a period of 7, 21, 42 and 84 days. The bone glue in its characteristics, has a good biocompatibility without any inflammatory tissue reaction and a good absorption. A regular fracture healing after adequate reduction can be observed, without being a barrier for cellular migration and osteogenesis.


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Christian HeissM.D. 

Department of Trauma Surgery, Justus-Liebig-University Giessen

(Laboratory of Experimental Trauma Surgery)

Rudolf-Buchheim-Strasse 7

35385 Giessen


Phone: +49/6 41/9 94 46 00

Fax: +49/6 41/9 94 46 09

Email: christian.heiss@chiru.med.uni-giessen.de