Abstract
The aim of this experimental study was to verify the biocompatibility of a new bone
glue in a fracture model in rabbits. The fracture healing after the glue application
and osseointegration were to be analyzed through histological and radiological invastigations.
36 rabbits were operated unifemoral and observed over a period of 7, 21, 42 and 84
days. The bone glue in its characteristics, has a good biocompatibility without any
inflammatory tissue reaction and a good absorption. A regular fracture healing after
adequate reduction can be observed, without being a barrier for cellular migration
and osteogenesis.
Key words
Bone glue - methacrylates - biocompatibility - histological light microscopy - experimental
study
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Christian HeissM.D.
Department of Trauma Surgery, Justus-Liebig-University Giessen
(Laboratory of Experimental Trauma Surgery)
Rudolf-Buchheim-Strasse 7
35385 Giessen
Germany
Phone: +49/6 41/9 94 46 00
Fax: +49/6 41/9 94 46 09
Email: christian.heiss@chiru.med.uni-giessen.de
