Synthesis of Novel Glycopeptidomimetics Containing O- and N-Glycosylated α-Aminooxy Acids by Fragment Coupling on Solid Support
17 September 2002 (online)
New glycosylated peptidomimetics possessing O- and N-glycosylated α-aminooxy acids were efficiently synthesized by fragment coupling on solid support. The N-terminal glycosylated tripeptide mimics prepared in solution were coupled to the C-terminal dipeptides attached to the resin under O-(7-azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU)/1-hydroxy-7-azabenzotriazole (HOAt)/N-ethylmorpholin (NEM) conditions.
α-aminooxy acids - carbohydrates - coupling - glycopeptidomimetics - solid-phase synthesis