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Synthesis 2002(11): 1502-1504
DOI: 10.1055/s-2002-33337
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

An Expeditious Solvent Free Synthesis of Functionalised Thietanes by
Nucleophile-Induced Cyclisation of O,O-Diethyl S-(1,3-Diaryl-3-oxopropyl) Phosphorodithioates

Lal Dhar S. Yadav*, Ritu Kapoor
Department of Chemistry, University of Allahabad, Allahabad 211 002, India
Fax: +91(532)545021; e-Mail: lds-yadav@hclinfinet.com;
Further Information

Publication History

Received 15 April 2002
Publication Date:
23 August 2002 (online)

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Abstract

An expeditious and highly diastereoselective synthesis of (Z)-2-alkylsulfenyl(or 2-cyano)-2,4-diarylthietanes 5a-i by nucleophile (CN-, RS-) induced cyclisation of O,O-diethyl S-(1,3-diaryl-3-oxopropyl) phosphorodithioates 3a-c under microwave irradiation in solvent free conditions is reported.

Key words

thietanes - phosphorodithioates - solvent free - microwave - cyclizations - stereoselective synthesis