Abstract
A novel and stereoselective approach to tetrodotoxin is described.
The tricyclic compound having several key functional groups on the
cyclohexane ring was synthesized from p -anisaldehyde
with control of the four chiral centers. Iodoaminocyclization, 1,3-dipolar
cycloaddition, and Baeyer-Villiger oxidation are the key
steps of our approach.
Key words
tetrodotoxin - stereoselective - iodoaminocyclization reaction - intramolecular 1,3-dipolar
cycloaddition - isoxazoline
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