Synthesis 2002(8): 1010-1012
DOI: 10.1055/s-2002-31967
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

A New Strategy for the Synthesis of Furan-3,4-dicarboxylic Acid [1]

Anil M. Deshpande, Arvind A. Natu, Narshinha P. Argade*
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India
Fax: +91(20)5893153; e-Mail: argade@dalton.ncl.res.in;
Weitere Informationen

Publikationsverlauf

Received 15 February 2002
Publikationsdatum:
03. Juni 2002 (online)

Abstract

A facile route to furan-3,4-dicarboxylic acid is described. Dimethylmaleic anhydride (1) on NBS-bromination followed by aqueous KOH treatment gave bis(hydroxymethyl)maleic anhydride (3), which on intramolecular Mitsunobu ring closure followed by esterification and DDQ-oxidation furnished the desired esters of furan-3,4-dicarboxylic acid 7a/b.

1

NCL Communication No. 6620.

1

NCL Communication No. 6620.

19

Deshpande, A. M.; Natu, A. A.; Argade, N. P., Unpublished results.