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Dtsch Med Wochenschr 2002; 127(18): 971-977
DOI: 10.1055/s-2002-26735
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© Georg Thieme Verlag Stuttgart · New York

Polyzystisches Ovarsyndrom und metabolisches Syndrom

Polycystic ovary syndrome and metabolic syndromeC. J. Auernhammer, D. Engelhardt, K. G. Parhofer
  • 1Medizinische Klinik II Großhadern, Klinikum der Ludwig Maximilians Universität München
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Publication History

15.1.2001

19.3.2002

Publication Date:
02 May 2002 (online)

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Das Krankheitsbild des polyzystischen Ovarsyndroms (PCOS) ist definiert durch eine primär ovarielle Hyperandrogenämie und chronische Anovulation. Mit einer Prävalenz von 5-7 % stellt das PCOS eine der häufigsten gynäkologisch-endokrinologischen Erkrankungen dar. Als ein wesentlicher pathogenetischer Faktor besteht häufig eine Insulinresistenz. Überdurchschnittlich häufig finden sich auch eine gestörte Glukosetoleranz oder ein Diabetes mellitus Typ 2, eine Adipositas oder ein metabolisches Syndrom. Die Assoziation von kardiovaskulären Risikofaktoren legt eine erhöhte kardiovaskuläre Morbidität und Mortalität nahe. Aktuelle klinische Studien zeigen positive Effekte von Gewichtsreduktion, Metformin und Insulinsensitizern nicht nur auf die Insulinresistenz und das metabolische Syndrom, sondern auch auf die Hyperandrogenämie und die ovarielle Dysfunktion. Ziel dieser Übersichtsarbeit ist es, die zentrale Rolle der Insulinresistenz in der Pathogenese des PCOS darzustellen und aktuelle Therapiemöglichkeiten der Insulinresistenz beim PCOS zu diskutieren.

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Dr. med. Christoph J. Auernhammer

Medizinische Klinik II, Klinikum der Ludwig-Maximilians-Universität, Standort Grosshadern

Marchioninistr. 15

81377 München

Phone: +49/89/70950

Fax: +49/89/7004418

Email: Christoph.Auernhammer@med2.med.uni-muenchen.de