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Dtsch Med Wochenschr 2002; 127(16): 859-865
DOI: 10.1055/s-2002-25188
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© Georg Thieme Verlag Stuttgart · New York

Stellenwert niedermolekularer Heparine in der Therapie akuter koronarer Syndrome

Low-molecular heparins in the treatment of the acute coronary syndromeJ. Carlsson, U. Tebbe
  • 1Medizinische Klinik II (Chefarzt: Prof. Dr. Ulrich Tebbe), Klinikum Lippe, Detmold
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Publication History

10.12.2001

14.3.2002

Publication Date:
18 April 2002 (online)

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Die Therapie akuter koronarer Syndrome - instabile Angina pectoris und akuter Herzinfarkt - hat sich in den letzten Jahren durch aktuelle Studienergebnisse verändert. Diese Veränderungen beruhen zum einen auf pharmakologischen Neuerungen wie der Plättcheninhibitortherapie mit Clopidogrel und Glykoprotein IIb/IIIa-Antagonisten. Zum anderen hat die Troponinbestimmung zu einer besseren Risikostratifizierung des Patienten mit akutem koronaren Syndrom geführt, so dass Entscheidungen über ein frühes invasives oder konservatives Vorgehen in der Akutsituation möglich sind. Während sich die direkten Thrombininhibitoren in dieser klinischen Situation nicht haben etablieren können, kommt der antithrombotischen Therapie mit niedermolekularen Heparinen (LMWH) als Ersatz für das seit Jahrzehnten verwendete unfraktionierte Heparin (UFH) große Bedeutung zu. Im Folgenden wird der Stellenwert der LMWH in der Therapie akuter koronarer Syndrome vor dem Hintergrund aktueller Studienergebnisse dargestellt.

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Priv.-Doz. Dr. med. Jörg Carlsson

Medizinische Klinik II
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