Nucleophilic Trifluoromethylation of N-Tosyl Aldimines
31 December 2001 (online)
TMSCF3 and tetrabutylammonium (triphenylsilyl) difluorosilicate (TBAT) were used for efficient nucleophilic trifluoromethylation to N-tosyl aldimines. Aromatic, aliphatic and α,β-unsaturated sulfonaldimines were efficiently trifluoromethylated to obtain the corresponding sulfonamide adducts in good to excellent yields.
amines - drugs - imines - nucleophilic addition - sulfonamides