Synthetic Studies towards Mniopetals (III). Solid Phase Organic Synthesis of a Key Intermediate for Combinatorial Synthesis of Mniopetals, Kuehneromycins and Marasmanes
31 December 2001 (online)
The Solid Phase Organic Synthesis (SPOS) of an advanced building block for mniopetals, kuehneromycins, marasmanes and libraries thereof is presented. The synthesis is a sequence of a Michaelis-Arbuzov reaction, Horner-Wadsworth-Emmons reaction, hydroboration/oxidation, IBX oxidation, a new variant of the Baylis-Hillman reaction and a domino Dess-Martin oxidation/Intramolecular Diels-Alder reaction.
solid phase synthesis - Michaelis-Arbuzov reaction - Horner-Wadsworth-Emmons reaction - oxidation - intramolecular Diels-Alder reaction