Convenient Synthesis of a New Class of N2SO or N2S2 Tetradentate Ligands Suitable for Nuclear Medicine Applications
31 December 2001 (online)
In our search for a 99mTc labelled brain perfusion imaging agent, six new tetradentate acyclic ligands have been synthesised in good yield, through easy and fast syntheses. These compounds possess an aromatic ring bridging a nitrogen and an oxygen or a sulfur and contain two amides (1a, 1b) or an amine and an amide functionalities (2a-2d), which make them good candidates for radiopharmaceuticals.
tetradentate ligands - 99mTc-complexes - amine - amide - radiopharmaceuticals