A Simple and very Efficient Route to New Chiral Ferrocenyl Diamines via Diastereoselective Alkylation
31 December 2001 (online)
A new family of chiral ferrocenyl diamines bearing one planar chirality and one or two stereogenic centers has been easily synthesized starting from 2-(N,N-dimethylaminomethyl)ferrocenylcarboxaldehyde (1) via a highly diastereoselective step. All diamines were obtained in high diastereomeric excesses and optical purities (de and ee >98%) and in 80% to 85% yields.
diamines - diastereoselectivity - N,N-dimethylaminomethylferrocene - imines - organometallic reagents