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Synlett 2001; 2001(12): 1956-1958
DOI: 10.1055/s-2001-18769
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The Selective Deprotection of Thioesters Using Titanium(IV) Chloride/Zinc

Chung Keun Jin* , Hyung Jae Jeong, Min Kyu Kim, Ju Young Kim, Young-Jin Yoon, Sang-Gyeong Lee
  • *Department of Chemistry, Division of Applied Life Science and Research Institute of Natural Science, Gyeongsang National University, Jinju 660-701, Korea
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Publication Date:
04 December 2001 (online)

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A new method for deprotection of thioesters using TiCl4/Zn at 0-25 °C is described. The procedure chemoselectively cleaves the S-CO bond in thioesters in the presence of other carbonyl functional groups and other protecting groups to cleanly produce thiols.

deprotection - chemoselectively - thiols - titanium chloride(IV) - thioester cleavage

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