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Synlett 2001; 2001(12): 1980-1982
DOI: 10.1055/s-2001-18752
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Palladium/Tetraphosphine Catalysed Heck Reaction with ortho-Substituted Aryl Bromides

Marie Feuerstein* , Henri Doucet, Maurice Santelli
  • *Laboratoire de Synthèse Organique associé au CNRS, Faculté des Sciences de St-Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France; Fax: + 33(491)983865; E-mail: henri.doucet@lso.u-3mrs.fr; E-mail: m.santelli@lso.u-3mrs.fr
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Publication Date:
04 December 2001 (online)

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The tetraphosphine cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane associated to [PdCl(C3H5)]2 catalyses the Heck reaction of butyl acrylate with a wide range of sterically demanding aryl bromides, furnishing the addition product in high yields. Turnover numbers as high as 630-89 000 have been obtained using ortho-substituted aryl bromides and 43-2600 with di-ortho-substituted aryl bromides in the presence of this catalyst.

catalysis - palladium - tetraphosphine - Heck reaction - aryl bromides

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