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Synlett 2001; 2001(12): 1869-1872
DOI: 10.1055/s-2001-18741
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Total Synthesis of the Furanocembrane bis-Deoxylophotoxin

Manuel Cases* , Felix González-López de Turiso, Gerald Pattenden
  • *School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, U. K; E-mail: gp@nottingham.ac.uk
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Publication History

Publication Date:
04 December 2001 (online)

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A total synthesis of the bis-deoxylophotoxin 25a, the probable biological precursor to the neurotoxin lophotoxin 1 is described. The synthesis uses a strategy based on sequential carbanion alkylation and Stille coupling between the chiral building blocks 5 and 6, leading to the furanocembranolide 23, following by functional group manipulation.

furanocembranes - lophotoxin - Stille macrocyclisation

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