Synthesis 2001(16): 2431-2434
DOI: 10.1055/s-2001-18722
PAPER
© Georg Thieme Verlag Stuttgart · New York

Dry Column Vacuum Chromatography

Daniel Sejer Pedersen*, Christoph RosenbohmCureon A/S, Fruebjergvej 3, 2100 Copenhagen, Denmark
Fax: +4570260097; e-Mail: ds@cureon.com;
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Publication History

Received 5 August 2001
Publication Date:
05 August 2004 (online)

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Abstract

Chromatographic purification is an integrated part of organic synthesis. The Dry Column Vacuum Chromatography presented here, has excellent resolving power, is easily applied to large scale chromatography (up to 100 g) and is fast. Furthermore, the technique is economical and environmentally friendly due to significant reductions in solvent and the amount of silica used. Therefore, it is an excellent alternative to the commonly used Flash Column Chromatography for purification in organic synthesis.

Key words

liquid chromatography - purification - large scale chromatography