Enaminones Acylation: Competitive Formation of Quinolin-4-one and Isoquinolin-1-one Derivatives

Abstract

The reaction of enaminones with some o-halogenobenzoyl chlorides allows the preparation of 3-acyl-2-alkylquinolin-4-one and/or 4-acyl-3-alkylisoquinolin-1-one derivatives depending on the structure of the starting materials. Due to their easy availability the compounds prepared are attractive precursors for further synthesis of polycondensed heterocycles.

Key words

acylation - enaminones - heterocycles - quinolines - isoquinolines

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18

The crystallographic data have been deposited at the Cambrige Crystallographic Data Center. The registration numbers are: 171351(6bd), 171352(7bc), and 171353(9).