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Synlett 2001; 2001(11): 1755-1758
DOI: 10.1055/s-2001-18103
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The Studies of the Intramolecular C-F-H-N Hydrogen Bonding Using Covalently-Linked Base Pair Models of F and A

Norio Shibata* , Biplab K. Das, Kazuyuki Harada, Yoshio Takeuchi, Masahiko Bando
  • *Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan; Fax + 81(76)4 34 46 56; E-mail: nozshiba@ms.toyama-mpu.ac.jp
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Publication Date:
29 October 2001 (online)

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Both 1H NMR and X-ray studies revealed that C-F-H-N intramolecular hydrogen bonding is not observed even in covalently-linked base pair models of F and A. These results strongly support the Kool's hypothesis.

nucleobases - intramolecular - hydrogen bonding - fluorine - DNA

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