Synthesis 2001(12): 1780-1783
DOI: 10.1055/s-2001-17533
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 6-Hydroxybenzothiazole-2-carboxylic Acid

Dennis W. P. M. Löwikb, Lawrence C. Tisi*a, James A. H. Murraya, Christopher R. Loweaa Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK
Fax: +44(1223)334162; e-Mail: lct11@mole.cam.ac.uk;
b Department of Organic Chemistry, University of Nijmegen, Toernooiveld, I-U 171, 6525 ED Nijmegen, The Netherlands
Further Information

Publication History

Received 1 March 2001
Publication Date:
11 August 2004 (online)

Abstract

The synthesis of 6-hydroxybenzothiazole-2-carboxylic acid (1) is presented. The benzothiazole ring was obtained by ring contraction of a remarkably stable 2-alkoxy-7-hydroxy-2H-benzo[1,4]thiazine intermediate that could be isolated. 6-Hydroxybenzothiazole-2-carboxylic acid was found to slowly decarboxylate in solution at ambient temperature.