Synlett 2001; 2001(10): 1511-1515
DOI: 10.1055/s-2001-17479
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Stereoselective Synthesis of Tri- and Tetrasubstituted α,β-Unsaturated Esters via Copper-catalyzed Coupling of Enol Triflates of β-Ketoesters with Grignard-based Zinc Ate Complexes

Mitsuaki Ide* , Masaya Nakata
  • *Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan; Fax + 81(45)5 66 15 51; E-mail: msynktxa@applc.keio.ac.jp
Further Information

Publication History

Publication Date:
27 September 2001 (online)

Tri- and tetrasubstituted α,β-unsaturated esters were stereoselectively prepared via the copper-catalyzed couplings of the enol triflates of β-ketoesters with Grignard-based zinc ate complexes. Some insights into the mechanistic considerations are described.

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