Download PDF
Synlett 2001; 2001(10): 1516-1518
DOI: 10.1055/s-2001-17455
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of a PNA-Peptide Conjugate by Chemical Ligation

Martijn C. de Koning* , Dmitri V. Filippov, Nico Meeuwenoord, Mark Overhand, Gijsbert A. van der Marel, Jacques H. van Boom
  • *Leiden Institute of Chemistry, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Fax + 31(71)52 74 30; E-mail: j.boom@chem.leidenuniv.nl
Further Information

Publication History

Publication Date:
27 September 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

A convergent synthetic route to the construction of a PNA-N-to-C-peptide conjugate (PKKKRKVGC-ttgcatt) by regioselective condensation of a thioester peptide and a cysteine-PNA adduct under denaturating conditions is described.

native chemical ligation - PNA-peptide conjugate - nuclear localization signal - convergent synthesis

      >