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Synlett 2001; 2001(10): 1575-1577
DOI: 10.1055/s-2001-17454
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Ring Expansion: Synthesis of the Velbanamine Piperidine Core

Janine Cossy* , Olivier Mirguet, Domingo Gomez Pardo
  • *Laboratoire de Chimie Organique associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France; Fax + 33(1)40 79 46 60; E-mail: janine.cossy@espci.fr
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Publication Date:
27 September 2001 (online)

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A ring expansion reaction applied to a substituted prolinol has been used in order to obtain the piperidine core of (-)-velbanamine, an alkaloid extracted from Tabernaemontana eglandulosa.

(-)-velbanamine - alkaloid - ring expansion - piperidines - trans-4-hydroxy-(l)-proline